Rainbow at shoreline

The Massachusetts ME/CFS & FM Association, a 501(c)3 founded in 1985, exists to meet the needs of patients with ME (Myalgic Encephalomyelitis), CFS (Chronic Fatigue Syndrome) or FM (Fibromyalgia), their families and loved ones. The Massachusetts ME/CFS & FM Association works to educate health-care providers and the general public regarding these severely-disabling physical illnesses. We also support patients and their families and advocate for more effective treatment and research.

Resources re ME/CFS for Long COVID clinics

A significant sub-set of Long COVIDpatients have symptoms that are consistent with a diagnosis of ME/CFS:

  1. Reduction or impairment in ability to carry out normal daily activities, accompanied by profound fatigue;
  2. Post-exertional malaise (worsening of symptoms after physical, cognitive, or emotional effort);
  3. Unrefreshing sleep;
  4. And either
    1. Cognitive impairment; or
    2. Orthostatic intolerance (symptoms that worsen when a person stands upright and improve when the person lies back down).

Other common manifestations of ME/CFS include pain, failure to recover from a prior infection, and abnormal immune function.

These symptoms may occur alone or along with other manifestations common to Long COVID.

Patients who have symptoms consistent with ME/CFS should be treated as ME/CFS patients, which includes guidance on energy management (e.g. pacing) and only a slow and carefully monitored re-introduction of exercise and resumption of normal activities.


IOM 2015 Diagnostic Criteria for ME/CFS (CDC)

US ME/CFS Clinician Coalition Diagnostic Guidelines


ICD-10-CM Coding for the diagnosis

Effective October 1, 2022, updates to the US ICD-10-CM will enable tracking of people with ME/CFS, including those who develop the disease following COVID. These updates are specific to the ICD-10-CM, the US version of the International Classification of Diseases.

Updated Coding for ME/CFS and ME/CFS following Long COVID

Background information regarding this change


Clinical care

Clinical Care of Patients with ME/CFS (CDC)

US ME/CFS Clinicians Coalition Testing Recommendations

US ME/CFS Clinicians Coalition Treatment Recommendations

Mayo Clinic: ME/CFS Essentials Of Diagnosis and Management

AAPM&R consensus guidance statements

Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS-CoV-2 infection (PASC) patients

Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of cognitive symptoms in patients with post-acute sequelae of SARS-CoV-2 infection (PASC)

Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of breathing discomfort and respiratory sequelae in patients with post-acute sequelae of SARS-CoV-2 infection (PASC)

Multi-Disciplinary Collaborative Consensus Guidance Statement on the Assessment and Treatment of Cardiovascular Complications in Patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) The full text of this article is currently available as a PDF.



Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome (2019)

Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — Dr. Anthony Komaroff, Dec 17, 2021. Grand Rounds presentation: 44 minute video. 


ME/CFS in Children

ME/CFS in Children (CDC)

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer (2017)



The Ronald G. Tompkins Harvard ME/CFS Collaboration at the Harvard Affiliated Hospitals


Long COVID - Lessons Learned from ME/CFS

What is Long COVID?

As of mid-February, 2022, over 78 million cases of COVID-19 have been reported in the U.S., with well over 900,000 deaths(1).

About 10 – 20% of people who have COVID-19, including people who have only mild symptoms, do not fully recover. Many of these people experience a variety of symptoms for many months. This is being called “Long COVID.”

Estimates from January, 2022, are that 20 million or more people in the U.S. have developed Long COVID. In Massachusetts 387,000 people may have Long COVID(2).

Long COVID is a “post-viral” illness.

Read more: Long COVID - Lessons Learned from ME/CFS

Notice about names

The Massachusetts ME/CFS & FM Association would like to clarify the use of the various acronyms for Chronic Fatigue Syndrome (CFS), Chronic Fatigue & Immune Dysfunction Syndrome (CFIDS) and  Myalgic Encephalomyelitis (ME) on this site. When we generate our own articles on the illness, we will refer to it as ME/CFS, the term now generally used in the United States. When we are reporting on someone else’s report, we will use the term they use. The National Institutes of Health (NIH) and other federal agencies, including the CDC, are currently using ME/CFS. 

Massachusetts ME/CFS & FM Association changed its name in July, 2018, to reflect this consensus.