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Important notice: Please note that the information on Treatment provided here has been compiled by patients for patients, and represents a summary of what patients may have experienced in working with their individual health care providers. The information in this website is not a substitute for professional medical advice. Please consult with your physician or other healthcare provider in matters pertaining to your medical care. See our full Medical Disclaimer.


Health Care Providers: Please see the information in ME/CFS: A Primer for Clinical Practitioners.


Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia (FM) is making considerable progress, which has generated enthusiasm even within the medical community, and will hopefully provide more definitive answers to the cause and cure. Meanwhile, there are various options and strategies that can be used as part of a treatment plan for people with these illnesses. Standard treatment usually consists of prescription medications to help relieve the most troublesome symptoms. But patients can tap into the different disciplines, like naturopathic medicine and alternative therapies, by which to improve their overall health and lifestyle.

ME/CFS and FM share a fair number of symptoms (i.e. sleep disorder, pain, decreased energy and cognitive functioning dificulties) and many individuals have both illnesses, though one tends to be more dominant. For practical reasons, information about the most commonly used medications and treatments for ME/CFS and FM have been combined on our website.

It is important to remember results can vary greatly between patients, and effective treatment plans often come from a "trial and error" process. Furthermore, many patients with ME/CFS are found to have a heightened sensitivity to medications and often cannot tolerate standard dosages. Medication titration is often recommended—a process by which a drug dosage is slowly brought up to achieve optimal therapeutic effect. It is also better for patients not to start out on too many medications or products at once, in order to better observe the effects (or side effects) of each. Then again, some physicians will prescribe several medications together, in small to modest amounts, to produce a synergistic effect.

Since patients with ME/CFS and FM often see several physicians and/or other practitioners and take a mixture of prescription drugs and other products, it is strongly advised they review everything they are taking with each and every doctor to prevent interactions.

The multi-pronged approach

ME/CFS and FM are known to generate a multitude of symptoms and problems, though these can vary between patients. It does not seem very likely that one single drug or therapy will provide adequate treatment for anyone. Effective treatment plans could consist of several elements from each of the following approaches/modalities listed below:

  • Conventional Medicine—Conventional medicine is a system that relies heavily on scientific research and technology and treats the disease and its symptoms by and large with pharmaceutical products. The primary objective is to help relieve or control symptoms and this is especially true for ME/CFS and FM. Even though these illnesses are still not fully understood, treatment will be geared towards alleviating the most disruptive symptoms, such as sleep disorder, pain, fatigue, cognitive disturbances, mood, infections, and cardiovascular and digestive problems.

  • Supplements, vitamins & herbal medicine—Herbal preparations, plant extracts, vitamins, and dietary supplements have been used as medicinal agents for many years. In many countries, these are prescribed by physicians, much like pharmaceuticals, and the manufacturers of these products are held to specified standards. Patients in the USA are left with the responsibility in navigating through all the various products and brands, which should not be taken lightly, but there are some guidelines in how they can go about this safely.

  • Lifestyle Management—When people are diagnosed with a new illness and/or their illness becomes chronic, it is always a good idea to become as well informed about it as possible and learn about different strategies and self-care skills. Knowledge can help people make better choices and feel more in control of their illness and situation. Patients will do better if they reevaluate what they still can do and make sensible adjustments and learn to pace themselves.

  • Mental Health—Many people are able to link the onset of ME/CFS or FM to a specific event (or soon thereafter) such as an infection, an accident, injury or surgery, or some other type of trauma. However, others will say that they have been struggling with various health problems since childhood. Whether people are learning to accept and adjust to a sudden change/decline in their health, or have been in poor health for a long time, this will often take a toll on people—physically, mentally and emotionally.

  • Nutrition & Exercise—Consuming more nutritious foods or eliminating those which may aggravate symptoms, and engaging in some level of physical activity can help to improve one's overall wellness. Though there are appreciable limits and consequences that ME/CFS and FM may impose, there are a number of things people can explore to help them stay as healthy, strong and mobile as possible.

  • Alternative Therapies—Naturopathic Medicine follows a different philosophy/paradigm of disease than conventional medicine, focusing more on the patient as a whole and not only on one's disease. Its approach is to tap into the body's inherent ability to heal and maintain itself and this is accomplished through a wide variety of modalities such as qigong, yoga, meditation/relaxation techniques, acupuncture, chiropractic care, and physical therapy, as well as using natural products. Many of these practices and therapies are gaining more support by the general medical community and are being recommended to patients—especially those with ME/CFS and FM.

More resources

Alternative Therapies

Antiviral treatment creates improvement in a subset of CFS/CFIDS/ME patients

Complementary & Mainstream Treatment Approaches by Dr. Jeanne Hubbuch

Comprehensive Treatment of FM by Dr. Robert Bennett

Conventional medicine

On the Morbid Fascination with Psychiatric Morbidity by Dr. Alan Gurwitt

Orthostatic Intolerance and CFS: A New Light on an Old Problem by Dr. Peter Rowe

Orthostatic Problems in CFIDS/FM and Post-Polio Syndrome  by Dr. Richard Bruno

Treatment for ME/CFS

Research Advances in the Chronic Fatigue Syndrome: Impact on Treatment by Dr. Nancy Klimas

Review of Nutritional Supplements used for ME/CFS & FM

Review of abnormal quantitative EEG (brainwave activity) results in CFIDS by Dr Frank Duffy, on Chronic Fatigue Syndrome/ Sleep/ The immune system, Radio National transcripts: The Health Report, 1997


The Physical Basis of CFS by Dr. Anthony Komaroff

Warning Against Long-term Use of SSRIs and Stimulants